The following articles discuss driving reaction time and/or cognition while taking chronic opioid therapy.

1. Byas-Smith MG, Chapman SL, Reed B, Cotsonis G. The Effect of Opioids on Driving and Psychomotor Performance in Patients With Chronic Pain. Clin J Pain. 2005;21:345–352.
2. Fishbain DA, Cutler RB, Rosomoff HL, Rosomoff S. Are Opioid-Dependent/Tolerant Patients. Impaired in Driving-Related Skills? A Structured Evidence-Based Review.  (Journal of Pain & Palliative Care.  Pharmacotherapy. 2003;16(1) 2002;9-28. Journal of Pain and Symptom Management.  June 2003; 25(6):559-576.)
3. Fishbain DA, Cutler RB, Rosomoff HL, Rosomoff S. Can Patients Taking Opioids Drive Safely? A Structured Evidence-Based Review.  Journal of Pain & Palliative Care Pharmacotherapy 2001;16(1);9-28.
4. Gaertner J. Radbruch L, Giesecke T, Gerbershagen H, Petzke F, Ostgathe C, Elsner F, Sabatowski R. Assessing cognition and psychomotor function under long-term treatment with controlled release oxycodone in non-cancer pain patients. Acta Anaesthesiol Scand 2006; 50: 664–672.
5. Galski T, Williams JB, Ehle HT. Effects of Opioids on Driving Ability. J Pain Symptom Manage 2000;19:200–208.
6. Menefee LA, Frank ED, Crerand C, Jalali S, Park J, Sanschagrin K, Besser M. The Effects of Transdermal Fentanyl on Driving, Cognitive Performance, and Balance in Patients with Chronic Nonmalignant Pain Conditions.  Pain Medicine. 2004;5(1):42-49.
7. Sabatowski R, Schwalen S, Rettig K, Herberg KW, Kasper SM, Radbruch L. Driving Ability Under Long-Term Treatment with Transdermal Fentanyl. J Pain Symptom Manage 2003;25:38–47.