The only other thing I take is a blood pressure pill Cartia 240 mg capsul and 50 mg of indomethacin for arthritis. I have been on it about 10 to 12 years. When I wait till late in the day to take it I might feel a little something if my stomach is empty and I drink caffeine with my methadone. Before methaone I was injured in a bad accident and placed on hydrocodone 10/325 and oxycontin 40 mg for years till my doctor retired. I came into methadone started at 30 mg move up to 60mg then had 3 peak and trough test settle in at 180mg its the right dose for me but no one can tell I take anything and neither can I . My doctor has a hard time believing I can\’t feel my dose any thoughts as to why.